PTAFR

Name

platelet activating factor receptor

Type

protein-coding

Position

28,147,166–28,194,083 (−)

Aliases

PAFR

Ensembl

ENSG00000169403

RefSeq RNA

NM_000952.5, NM_001164721.2, NM_001164722.3, NM_001164723.3

RefSeq protein

NP_000943.1, NP_001158193.1, NP_001158194.1, NP_001158195.1

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].

via MyGene.info

Gene · Ensembl

platelet activating factor receptor

Symbol

PTAFR

Biotype

Protein coding

Organism

Homo sapiens

Location

1:28,147,166-28,194,083

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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