PTK6
Sign in to saveAlso known as BRK, protein tyrosine kinase 6
Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.
Gene data
PTK6- Name
- protein tyrosine kinase 6
- Type
- protein-coding
- Position
- 63,528,001–63,537,376 (−)
- Aliases
- BRK
- Ensembl
- ENSG00000101213
- RefSeq RNA
- NM_001256358.2, NM_005975.4
- RefSeq protein
- NP_001243287.1, NP_005966.1
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
protein tyrosine kinase 6
- Symbol
- PTK6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:63,526,306-63,537,770
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PTK6 PDB 1rja.png
Show 5 more facts
- HomoloGene ID
- 68494
- exact match
- identifiers.org/ncbigene/5753
- genomic end
- 63537376
- genomic start
- 62159778
- cytogenetic location
- 20q13.33
Sources (3)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.
== Function ==
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via Wikidata sitelinks · CC0