PTPRN
Sign in to saveAlso known as IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, protein tyrosine phosphatase, receptor type N, protein tyrosine phosphatase receptor type N
Receptor-type tyrosine-protein phosphatase-like N, also called "IA-2", is an enzyme that in humans is encoded by the PTPRN gene.
Gene data
PTPRN- Name
- protein tyrosine phosphatase receptor type N
- Type
- protein-coding
- Position
- 219,289,623–219,309,648 (−)
- Aliases
- IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N
- Ensembl
- ENSG00000054356
- RefSeq RNA
- NM_001199763.2, NM_001199764.2, NM_002846.4
- RefSeq protein
- NP_001186692.1, NP_001186693.1, NP_002837.1
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
protein tyrosine phosphatase receptor type N
- Symbol
- PTPRN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:219,289,623-219,309,648
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~5 min read
Encyclopedic overview
8 sectionsContents
- Overview
- Structure
- Function
- Autoantigen in Type 1 Diabetes
- Autoantibodies in Type 1 Diabetes
- Interactions
- References
- Further reading
Receptor-type tyrosine-protein phosphatase-like N, also called "IA-2", is an enzyme that in humans is encoded by the PTPRN gene.
== Overview == The IA-2 protein encoded by PTPRN gene is a member of the protein tyrosine phosphatase (PTP) family and PTPRN subfamily. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Excerpted from Wikipedia’s “PTPRN” article, available under the CC BY-SA 4.0 licence.