SPTBN4

Also known as QV, SPNB4, SPTBN3, spectrin beta, non-erythrocytic 4, CMND, NEDHND

Spectrin, beta, non-erythrocytic 4, also known as SPTBN4, is a protein that in humans is encoded by the SPTBN4 gene.

In the Vinony graph

Vinony's link graph records 275 inbound references to SPTBN4, and connects out to hair keratin, PubMed and human chromosome 19.

It is catalogued under the topic Genes on human chromosome 19.

Vinony links it to 5 Wikipedia language editions.

Gene data

SPTBN4

Name: spectrin beta, non-erythrocytic 4
Type: protein-coding
Position: 40,466,241–40,576,464 (+)
Aliases: CMND, NEDHND, QV, SPNB4, SPTBN3
Ensembl: ENSG00000160460
RefSeq RNA: NM_020971.3, NM_025213.3, XM_017027049.2, XM_017027050.2, XM_017027051.2
RefSeq protein: NP_066022.2, NP_079489.2, XP_016882538.1, XP_016882539.1, XP_016882540.1

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways

Developmental Biology Developmental Biology Signal Transduction ER to Golgi Anterograde Transport Membrane Trafficking L1CAM interactions L1CAM interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Metabolism of proteins

via MyGene.info

Gene · Ensembl

spectrin beta, non-erythrocytic 4

Symbol: SPTBN4
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:40,466,241-40,576,464
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 11879
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/57731
genomic end: 41082370
genomic start: 40972148
chromosome: human chromosome 19
cytogenetic location: 19q13.2
expressed in: pituitary gland

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

Spectrin, beta, non-erythrocytic 4, also known as SPTBN4, is a protein that in humans is encoded by the SPTBN4 gene.

Spectrin is an actin crosslinking and molecular scaffold protein that links the cell membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in mice is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene.

Excerpted from Wikipedia’s “SPTBN4” article, available under the CC BY-SA 4.0 licence.