PUF60
Sign in to saveAlso known as FIR, RoBPI, SIAHBP1, VRJS, poly(U) binding splicing factor 60KDa, poly(U) binding splicing factor 60
Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.
Gene data
PUF60- Name
- poly(U) binding splicing factor 60
- Type
- protein-coding
- Aliases
- FIR, RoBPI, SIAHBP1, VRJS
This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
via MyGene.info
Gene · Ensembl
poly(U) binding splicing factor 60
- Symbol
- PUF60
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:143,816,344-143,830,709
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 8614
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/22827
- chromosome
- human chromosome 8
- genomic start
- 144898514
- genomic end
- 143829352
- cytogenetic location
- 8q24.3
- expressed in
- putamen
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.
The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.
Excerpted from Wikipedia’s “PUF60” article, available under the CC BY-SA 4.0 licence.