Structure via PubChem · Public domain (PubChem)
pyronaridine
Sign in to savePyronaridine is an antimalarial drug. It was first made in 1970 and has been in clinical use in China since the 1980s.
In the Vinony graph
Vinony's link graph records 71 inbound references to pyronaridine, and connects out to antimalarial, artesunate/pyronaridine and medication.
It sits within the topics Antimalarial agents, Chemical pages without DrugBank identifier and Chinese discoveries.
Vinony links it to 8 Wikipedia language editions.
Chemical data
- Formula
- C29H32ClN5O2
- Molecular weight
- 518 g/mol
- IUPAC name
- 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
- SMILES
- COC1=NC2=C(C3=C(C=C(C=C3)Cl)N=C2C=C1)NC4=CC(=C(C(=C4)CN5CCCC5)O)CN6CCCC6
- InChIKey
- DJUFPMUQJKWIJB-UHFFFAOYSA-N
- XLogP
- 5.3
- Polar surface area
- 73.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- malaria, Plasmodium falciparum malaria, urinary schistosomiasis, COVID-19
via ChEMBL · EBI
Research
419 papers- Pyronaridine: a review of its clinical pharmacology in the treatment of malaria.The Journal of antimicrobial chemotherapy · 2023
- Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.The Cochrane database of systematic reviews · 2022
- Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.The Cochrane database of systematic reviews · 2019
- Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.The Cochrane database of systematic reviews · 2025
- Pyronaridine: An update of its pharmacological activities and mechanisms of action.Biopolymers · 2021
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 517.224452944
Show 4 more facts
- chemical formula
- C₂₉H₃₂ClN₅O₂
- canonical SMILES
- COC1=NC2=C(C3=C(C=C(C=C3)Cl)N=C2C=C1)NC4=CC(=C(C(=C4)CN5CCCC5)O)CN6CCCC6
- subject has role
- antimalarial
- found in taxon
- Acronychia pubescens
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Pyronaridine is an antimalarial drug. It was first made in 1970 and has been in clinical use in China since the 1980s.
In a small (n=88) malaria study in Cameroon, pyronaridine had a 100% cure rate, compared with 60% for chloroquine.
Excerpted from Wikipedia’s “pyronaridine” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0