RARB

Also known as HAP, MCOPS12, NR1B2, RRB2, RARbeta1, retinoic acid receptor beta, RARbeta

protein-coding gene in the species Homo sapiens

Gene data

RARB

Name: retinoic acid receptor beta
Type: protein-coding
Position: 24,687,887–25,597,932 (+)
Aliases: HAP, MCOPS12, NR1B2, RARbeta, RARbeta1, RRB2
Ensembl: ENSG00000077092
RefSeq RNA: NM_000965.5, NM_001290216.3, NM_001290217.2, NM_001290266.2, NM_001290276.2
RefSeq protein: NP_000956.2, NP_001277145.1, NP_001277146.1, NP_001277195.1, NP_001277205.1

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014].