REL

Also known as C-Rel, REL proto-oncogene, NF-kB subunit, HIVEN86A, IMD92

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.

Gene data

REL

Name: REL proto-oncogene, NF-kB subunit
Type: protein-coding
Position: 60,881,491–60,940,021 (+)
Aliases: C-Rel, HIVEN86A, IMD92
Ensembl: ENSG00000162924
RefSeq RNA: NM_001291746.2, NM_001438025.1, NM_002908.4, XM_011533010.4, XM_054343268.1
RefSeq protein: NP_001278675.1, NP_001424954.1, NP_002899.1, XP_011531312.1, XP_054199243.1

This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].

Gene Ontology

Biological process

negative regulation of cytokine production regulation of DNA-templated transcription canonical NF-kappaB signal transduction negative regulation of gene expression negative regulation of interferon-beta production response to cytokine non-canonical NF-kappaB signal transduction positive regulation of canonical NF-kappaB signal transduction

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm cytoplasm cytosol NF-kappaB complex

Pathways

Ras signaling pathway - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Downstream signaling events of B Cell Receptor (BCR)Activation of NF-kappaB in B cells Adaptive Immune System Immune System Signaling by the B Cell Receptor (BCR)IL-1 signaling pathway Leptin signaling pathway

via MyGene.info

Gene · Ensembl

REL proto-oncogene, NF-kB subunit

Symbol: REL
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:60,881,491-60,940,021
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 2182
genetic association: psoriatic arthritis
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5966
genomic end: 60931612
genomic start: 61108656
chromosome: human chromosome 2
cytogenetic location: 2p16.1
expressed in: superficial temporal artery

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

==References==

Excerpted from Wikipedia’s “REL” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

REL