رلوگولیکس

Also known as TAK 385, Relugolix

Relugolix, sold under the brand names Orgovyx and Relumina among others, is a gonadotropin-releasing hormone antagonist (GnRH receptor antagonist) medication which is used in the treatment of prostate cancer, uterine fibroids and endometriosis. It is taken by mouth.

Chemical data

Formula: C29H27F2N7O5S
Molecular weight: 623.6 g/mol
IUPAC name: 1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea
SMILES: CN(C)CC1=C(SC2=C1C(=O)N(C(=O)N2CC3=C(C=CC=C3F)F)C4=NN=C(C=C4)OC)C5=CC=C(C=C5)NC(=O)NOC
InChIKey: AOMXMOCNKJTRQP-UHFFFAOYSA-N
XLogP: 3.2
Polar surface area: 157 Å²
H-bond donors: 2
H-bond acceptors: 11
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
Admin. routes: oral
Indications: endometriosis, uterine fibroid, pain, prostate cancer

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 623.176244

Show 3 more facts

canonical SMILES: CN(C)CC1=C(SC2=C1C(=O)N(C(=O)N2CC3=C(C=CC=C3F)F)C4=NN=C(C=C4)OC)C5=CC=C(C=C5)NC(=O)NOC
chemical formula: C₂₉H₂₇F₂N₇O₅S
Commons category: Relugolix

Sources (3)

via Wikidata · CC0

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via Wikidata sitelinks · CC0