Structure via PubChem · Public domain (PubChem)
urofollitropin
Sign in to saveAlso known as Follitropin beta chain precursor, FSH, FSH-beta, FSH-B, Urofollitrophin, Follicle-stimulating hormone beta subunit, Follicle Stimulating Hormone, Metrodin
Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified to remove various proteins and other substances. FSH is important in the development of follicles (eggs) produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. It is also used with in vitro fertilization methods. The dosage is adjusted to each individual's response.
Chemical data
- Formula
- C42H65N11O12S2
- Molecular weight
- 980.2 g/mol
- IUPAC name
- 1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
- SMILES
- CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C(C)O
- InChIKey
- ZDRRIRUAESZNIH-UHFFFAOYSA-N
- XLogP
- -1.5
- Polar surface area
- 427 Ų
- H-bond donors
- 12
- H-bond acceptors
- 15
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Unknown
- First approval
- 1986
- Admin. routes
- parenteral
- Indications
- infertility, azoospermia, male infertility, anovulation
via ChEMBL · EBI
Research
78 papers- Urofollitropin and ovulation induction.Treatments in endocrinology · 2005
- Gonadotropins.2012
- [Clinical efficacy of Xuanju compound capsule combined with urofollitropin in the treatment of patients with idiopathic oligoasthenozoospermia].Zhonghua nan ke xue = National journal of andrology · 2023
- Testosterone levels after treatment with urofollitropin in infertile patients with idiopathic mild reduction of testicular volume.Endocrine · 2019
- Urofollitropin - Ferring: FERRING hFSH, hFSH - Ferring, human follicle-stimulating hormone - Ferring, Bravelle.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2003
via PubMed
Wikidata facts
- Subclass of
- gonadotropins
- Has part
- human follitropin
- Mass
- 979.425559
- Has use
- medication
Show 4 more facts
- canonical SMILES
- CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C(C)O
- chemical formula
- C₄₂H₆₅N₁₁O₁₂S₂
- medical condition treated
- polycystic ovary syndrome
- has characteristic
- biopharmaceutical
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified to remove various proteins and other substances. FSH is important in the development of follicles (eggs) produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. It is also used with in vitro fertilization methods. The dosage is adjusted to each individual's response.
The most common side effects are abdominal or pelvic pain, bloating, as well as redness, pain or swelling at the injection site. Follitropin is possibly associated with increased risk of endometrial carcinoma. It is not for use during pregnancy, as there is evidence for birth defects under follitropin treatment.
Excerpted from Wikipedia’s “urofollitropin” article, available under the CC BY-SA 4.0 licence.
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