REST

Name

RE1 silencing transcription factor

Type

protein-coding

Position

56,907,853–56,967,011 (+)

Aliases

DFNA27, GINGF5, HGF5, NRSF, WT6, XBR

Ensembl

ENSG00000084093

RefSeq RNA

NM_001193508.2, NM_001363453.3, NM_001440532.1, NM_001440533.1, NM_005612.5

RefSeq protein

NP_001180437.1, NP_001350382.1, NP_001427461.1, NP_001427462.1, NP_005603.3

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018].

via MyGene.info

Gene · Ensembl

RE1 silencing transcription factor

Symbol

REST

Biotype

Protein coding

Organism

Homo sapiens

Location

4:56,907,853-56,967,011

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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