retroviral integrase
Also known as retroviral integrases, integrase, integrases
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects. Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination.
Key facts
- Protein family.Symbol
- IN_DBD_C
- Protein family.Name
- Integrase DNA binding domain
- Protein family.image
- PDB 1c1a EBI.jpg
- Protein family.caption
- Crystal structure of the RSV two-domain integrase.
- Protein family.Pfam
- PF00552
- Protein family.InterPro
- IPR001037
- Protein family.SCOP
- 1ihw
- Protein family.Pfam_clan
- CL0219
via Wikipedia infobox
Article
9 sectionsContents
- Structure
- Function and mechanism
- In HIV
- Integration mechanism
- Antiretroviral therapy
- See also
- References
- Further reading
- External links
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects. Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination.
The macromolecular complex of an IN macromolecule bound to the ends of the viral DNA ends has been referred to as the intasome; IN is a key component in this and the retroviral pre-integration complex.