Интеграза
Also known as retroviral integrases, integrase, integrases
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects. Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination.
Key facts
- Protein family.Symbol
- IN_DBD_C
- Protein family.Name
- Integrase DNA binding domain
- Protein family.image
- PDB 1c1a EBI.jpg
- Protein family.caption
- Crystal structure of the RSV two-domain integrase.
- Protein family.Pfam
- PF00552
- Protein family.InterPro
- IPR001037
- Protein family.SCOP
- 1ihw
- Protein family.Pfam_clan
- CL0219
via Wikipedia infobox
Wikidata facts
Show 1 more fact
- Commons category
- Integrase, retroviral
Sources (3)
Article · Русский
Интеграза (IN) — фермент, катализирующий интеграцию (включение) ДНК вируса (ретровируса, в частности, ВИЧ) в хромосому клетки-хозяина. Перед интеграцией линейные молекулы ДНК вируса сначала замыкаются в кольцо и затем уже встраиваются. Ретровирусные интегразы — ключевой компонент прединтеграционного комплекса (PIC). Сходные ферменты фагов — phage integrase, например λ phage integrase (Int).
Abstract from DBpedia / Wikipedia · CC BY-SA