RFX3

Also known as regulatory factor X3

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.

Gene data

RFX3

Name: regulatory factor X3
Type: protein-coding
Position: 3,218,297–3,526,022 (−)
Ensembl: ENSG00000080298
RefSeq RNA: NM_001282116.2, NM_001282117.2, NM_001377999.1, NM_002919.4, NM_134428.3
RefSeq protein: NP_001269045.1, NP_001269046.1, NP_001364928.1, NP_002910.1, NP_602304.1

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013].

Gene Ontology

Biological process

DNA-templated transcription regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II endocrine pancreas development endocrine pancreas development negative regulation of DNA-templated transcription positive regulation of DNA-templated transcription

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA binding

Cellular component

chromatin chromatin chromatin extracellular region nucleus nucleus nucleus nucleus

via MyGene.info

Wikidata facts

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HomoloGene ID: 7917
exact match: identifiers.org/ncbigene/5991
genomic end: 3526004
genomic start: 3218297
cytogenetic location: 9p24.2

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Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.