rhodanine
Rhodanine is a 5-membered heterocyclic organic compound possessing a thiazolidine core. It was discovered in 1877 by Marceli Nencki who named it "Rhodaninsaure" in reference to its synthesis from ammonium rhodanide (known as ammonium thiocyanate to modern chemists) and chloroacetic acid in water.
Chemical data
- Formula
- C3H3NOS2
- Molecular weight
- 133.2 g/mol
- IUPAC name
- 2-sulfanylidene-1,3-thiazolidin-4-one
via PubChem
Research
1,057 papers- Rhodanine derivatives: An insight into the synthetic and medicinal perspectives as antimicrobial and antiviral agents.Chemical biology & drug design · 2023
- Drug screening of rhodanine derivatives for antibacterial activity.Expert opinion on drug discovery · 2020
- Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
- Arylidene and amino spacer-linked rhodanine-quinoline hybrids as upgraded antimicrobial agents.Chemical biology & drug design · 2023
- The Importance of Rhodanine Scaffold in Medicinal Chemistry: A Comprehensive Overview.
Article
2 sectionsContents
- Derivatives
- References
Rhodanine is a 5-membered heterocyclic organic compound possessing a thiazolidine core. It was discovered in 1877 by Marceli Nencki who named it "Rhodaninsaure" in reference to its synthesis from ammonium rhodanide (known as ammonium thiocyanate to modern chemists) and chloroacetic acid in water.
Rhodanines can also be prepared by the reaction of carbon disulfide, ammonia, and chloroacetic acid, which proceeds via an intermediate dithiocarbamate. 450px|frameless