epalrestat
Sign in to saveAlso known as 2-[(5Z)-5-[(E)-3-phenil-2-methylprop-2-enylidene]-4-oxo-2-thioxo-3-thiazolidinyl]acetic acid
Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. It reduces the accumulation of intracellular sorbitol which is believed to be the cause of diabetic neuropathy, retinopathy and nephropathy It is well tolerated, with the most commonly reported adverse effects being gastrointestinal issues such as nausea and vomiting, as well as increases in certain liver enzymes. Chemically, epalrestat is unusual in th
Wikidata facts
- Mass
- 319.03368527599997
Show 4 more facts
- chemical formula
- C₁₅H₁₃NO₃S₂
- isomeric SMILES
- C/C(=C\C1=CC=CC=C1)/C=C\2/C(=O)N(C(=S)S2)CC(=O)O
- canonical SMILES
- CC(=CC1=CC=CC=C1)C=C2C(=O)N(C(=S)S2)CC(=O)O
- Commons category
- Epalrestat
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3 sectionsContents
- Evidence
- Brand names
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{{Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 406013101 | ImageFile = Epalrestat.svg | ImageClass = skin-invert-image | ImageSize = 222 | PIN = {(5Z)-5-[(2E)-2-Methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl}acetic acid | OtherNames =
|Section1 =