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ripretinib
Sign in to saveAlso known as Qinlock, DCC-2618
Ripretinib, sold under the brand name Qinlock, is a medication for the treatment of adults with advanced gastrointestinal stromal tumor (GIST), a type of tumor that originates in the gastrointestinal tract. It is taken by mouth. Ripretinib inhibits the activity of the kinases KIT and PDGFRA, which helps keep cancer cells from growing.
Chemical data
- Formula
- C24H21BrFN5O2
- Molecular weight
- 510.4 g/mol
- IUPAC name
- 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea
- SMILES
- CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC
- InChIKey
- CEFJVGZHQAGLHS-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 86.4 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 509.0862652320001
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₄H₂₁BrFN₅O₂
- canonical SMILES
- CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)cc2c[nH]c(=NC)cc21
- subject has role
- protein kinase inhibitors
- medical condition treated
- gastrointestinal stromal tumor
Sources (1)
via Wikidata · CC0
~7 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Adverse effects
- History
- Society and culture
- Legal status
- Names
- References
- Further reading
- External links
{{Infobox drug | image = Ripretinib skeletal.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = rip re' ti nib | tradename = Qinlock | Drugs.com = | MedlinePlus = a620035 | DailyMedID = Ripretinib | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category= Use should be avoided | routes_of_administration = By mouth | class = | ATC_prefix = L01 | ATC_suffix = EX19 | ATC_supplemental =
Excerpted from Wikipedia’s “ripretinib” article, available under the CC BY-SA 4.0 licence.