Gene data
RNF8- Name
- ring finger protein 8
- Type
- protein-coding
- Position
- 37,353,970–37,394,737 (+)
- Aliases
- hRNF8
- Ensembl
- ENSG00000112130
- RefSeq RNA
- NM_003958.4, NM_183078.3, NR_046399.2
- RefSeq protein
- NP_003949.1, NP_898901.1
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
Gene Ontology
Biological process
double-strand break repairdouble-strand break repairdouble-strand break repairdouble-strand break repair via nonhomologous end joiningdouble-strand break repair via nonhomologous end joiningchromatin organizationubiquitin-dependent protein catabolic processubiquitin-dependent protein catabolic process
Molecular function
Pathways
Cell CycleDNA Double-Strand Break RepairHomology Directed RepairRecruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksHDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)Nonhomologous End-Joining (NHEJ)DNA Double Strand Break ResponseProcessing of DNA double-strand break endsG2/M DNA damage checkpointG2/M Checkpoints
via MyGene.info
Gene · Ensembl
ring finger protein 8
- Symbol
- RNF8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:37,353,970-37,394,737
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein RNF8 PDB 2csw.png
Show 7 more facts
- HomoloGene ID
- 2944
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9025
- genomic end
- 37394734
- genomic start
- 37353979
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.2
Sources (4)
via Wikidata · CC0