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GeneQ18033945· pop 5· linked from 303 articles

RPS6KA5

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Also known as MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

Gene data

RPS6KA5
Name
ribosomal protein S6 kinase A5
Type
protein-coding
Position
90,847,861–91,060,685 (−)
Aliases
MSK1, MSPK1, RLPK
Ensembl
ENSG00000100784
RefSeq RNA
NM_001322227.2, NM_001322228.2, NM_001322229.2, NM_001322230.2, NM_001322231.2
RefSeq protein
NP_001309156.1, NP_001309157.1, NP_001309158.1, NP_001309159.1, NP_001309160.1

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; positive regulation of histone modification; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Pathways

MAPK signaling pathway - Homo sapiens (human)Adrenergic signaling in cardiomyocytes - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Circadian entrainment - Homo sapiens (human)Neurotrophin signaling pathway - Homo sapiens (human)Shigellosis - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)MicroRNAs in cancer - Homo sapiens (human)Bladder cancer - Homo sapiens (human)Developmental Biology

via MyGene.info

Gene · Ensembl

ribosomal protein S6 kinase A5

Symbol
RPS6KA5
Biotype
Protein coding
Organism
Homo sapiens
Location
14:90,847,861-91,060,685
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

3 sections
Contents
  • Interactions
  • References
  • Further reading

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

==Interactions== RPS6KA5 has been shown to interact with CREB1.

Excerpted from Wikipedia’s “RPS6KA5” article, available under the CC BY-SA 4.0 licence.

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