Structure via PubChem · Public domain (PubChem)
(RS)-norketamine
Sign in to saveNorketamine, or '''N-desmethylketamine''', is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist, but is about 3–5 times less potent as an anesthetic in comparison.
In the Vinony graph
Within Vinony's link graph, (RS)-norketamine is referenced by 1,246 other articles, and connects out to allosteric modulator, barbiturates and antagonist.
It is catalogued under topics including 2-Chlorophenyl compounds, Analgesics and Antidepressants.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C12H14ClNO
- Molecular weight
- 223.7 g/mol
- IUPAC name
- 2-amino-2-(2-chlorophenyl)cyclohexan-1-one
- SMILES
- C1CCC(C(=O)C1)(C2=CC=CC=C2Cl)N
- InChIKey
- BEQZHFIKTBVCAU-UHFFFAOYSA-N
- XLogP
- 1.7
- Polar surface area
- 43.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 223.076
Show 2 more facts
- canonical SMILES
- C1CCC(C(=O)C1)(C2=CC=CC=C2Cl)N
- chemical formula
- C₁₂H₁₄ClNO
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
7 sectionsContents
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- References
Norketamine, or '''N-desmethylketamine', is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist, but is about 3–5 times less potent as an anesthetic in comparison.
== Pharmacology ==
Excerpted from Wikipedia’s “(RS)-norketamine” article, available under the CC BY-SA 4.0 licence.