Norketamine, or '''N-desmethylketamine''', is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist, but is about 3–5 times less potent as an anesthetic in comparison.
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).