(RS)-rabeprazole
Sign in to saveRabeprazole, sold under the brand name Aciphex, among others, is a medication that decreases stomach acid. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and excess stomach acid production such as in Zollinger–Ellison syndrome. It may also be used in combination with other medications to treat Helicobacter pylori. Effectiveness is similar to other proton pump inhibitors (PPIs). It is taken by mouth.
Key facts
- Drug.ATC_suffix
- BC04
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.S
- 1
- Drug.bioavailability
- 52%
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462080585
- Drug.image
- Rabeprazole enantiomers labelled.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 300
- Drug.image2
- Rabeprazole enantiomers ball-and-stick models from xtal 2011.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 300
- Drug.chirality
- Racemic mixture
- Drug.tradename
- Aciphex, Pariet, Rafron, others
- Drug.MedlinePlus
- a699060
- Drug.DailyMedID
- Rabeprazole
- Drug.licence_US
- Rabeprazole
via Wikipedia infobox
Research
23 papersvia PubMed
Article
39 sectionsContents
- Medical uses
- Available forms
- Specific populations
- Pediatrics
- Pregnancy
- Lactation
- Geriatrics
- Japanese ancestry
- Kidney or liver problems
- Contraindications
- Hypersensitivity
- Syndrome
- Cross-reactivity
- Rilpivirine
- Adverse effects
- Osteoporosis and fractures
- Infection risk
- Nephrotoxicity
- Muscle-related adverse events
- Overdose
- Interactions
- Drug-drug interactions
- Food-drug interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Pharmacogenetics
- Chemistry
- Synthesis
- Comparative chemistry
- Physiochemical properties
- History
- Development
- Society and culture
- Legal status
- Brand names
- Research
- References
- External links
Rabeprazole, sold under the brand name Aciphex, among others, is a medication that decreases stomach acid. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and excess stomach acid production such as in Zollinger–Ellison syndrome. It may also be used in combination with other medications to treat Helicobacter pylori. Effectiveness is similar to other proton pump inhibitors (PPIs). It is taken by mouth.
Common side effects include constipation, feeling weak, and throat inflammation. Serious side effects may include osteoporosis, low blood magnesium, Clostridioides difficile infection, and pneumonia. Use in pregnancy and breastfeeding is of unclear safety. It works by blocking H+/K+-ATPase in the parietal cells of the stomach.
Gallery (22)
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Categories
BenzimidazolesCYP2C19 inhibitorsDrugboxes which contain changes to watched fieldsDrugs developed by Johnson & JohnsonECHA InfoCard ID from WikidataEthersExternally peer reviewed articlesJanssen PharmaceuticaJapanese inventionsMultiple chemicals in an infobox that need indexingMultiple chemicals in Infobox drugPhenol ethers