File:Proton_pump_inhibitors_structure.svg · Wikimedia Commons · See Wikimedia Commons
proton-pump inhibitor
Sign in to saveAlso known as PPIs, Proton Pump Inhibitors, Proton Pump Inhibitor, PPI, proton-pump inhibitors
group of drugs whose main action is reduction of gastric acid production
Key facts
- Use
- Reduction of gastric acid production
- Atc code
- A02BC
- Mechanism of action
- Enzyme inhibitor
- Biological target
- H /K ATPase
- Drugs com
- Drug Classes
- Webmd
- MedicineNet
- Mesh
- D054328
via Wikipedia infobox
Research
33,962 papers- Rebuilding trust in proton pump inhibitor therapy.World journal of gastroenterology · 2022
- Efficacy and Safety of Clopidogrel With and Without a Proton Pump Inhibitor: A Systematic Review and Meta-Analysis.Basic & clinical pharmacology & toxicology · 2025
- Indications for the Use of Proton Pump Inhibitors for Stress Ulcer Prophylaxis and Peptic Ulcer Bleeding in Hospitalized Patients.The American journal of medicine · 2022
- Evidence for proton-pump inhibitor (PPI)-associated dysbiosis in metabolically unhealthy obesity.Frontiers in endocrinology · 2023
- [Proton pump inhibitor-induced nephrotoxicity].Nederlands tijdschrift voor geneeskunde · 2021
via PubMed
Wikidata facts
- Instance of
- drug class
- Subclass of
- enzyme inhibitor
Show 5 more facts
- Commons category
- Proton pump inhibitors
- topic's main category
- Category:Proton-pump inhibitors
- NCI Thesaurus ID
- C29723
- short name
- IBP
- subject has role
- essential medicine
via Wikidata · CC0
~13 min read
Encyclopedic overview
Proton-pump inhibitors (PPIs) are a class of medications that cause a profound and prolonged reduction of stomach acid production. They do so by irreversibly inhibiting the stomach's H/K ATPase proton pump. The body eventually synthesizes new proton pumps to replace the irreversibly inhibited ones—a process driven by normal cellular turnover, which gradually restores acid production.
Proton-pump inhibitors have largely superseded the H2-receptor antagonists, a group of medications with similar effects but a different mode of action, and heavy use of antacids. Potassium-competitive acid blockers (PCABs) have entered the market since the 2010s.
Excerpted from Wikipedia’s “proton-pump inhibitor” article, available under the CC BY-SA 4.0 licence.