Structure via PubChem · Public domain (PubChem)
troxipide
Sign in to saveAlso known as 3,4,5-Trimethoxy-N-(3-piperidyl)benzamide
Troxipide is a drug used in the treatment of gastroesophageal reflux disease. Troxipide is a systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum. Troxipide is currently marketed in Japan (Aplace), China (Shuqi), South Korea (Defensa), and India (Troxip). It is used for the management of gastric ulcers, and amelioration of gastric mucosal lesions in acute gastritis and acute exacerbation of chronic gastritis.
Chemical data
- Formula
- C15H22N2O4
- Molecular weight
- 294.35 g/mol
- IUPAC name
- 3,4,5-trimethoxy-N-piperidin-3-ylbenzamide
- SMILES
- COC1=CC(=CC(=C1OC)OC)C(=O)NC2CCCNC2
- InChIKey
- YSIITVVESCNIPR-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 68.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Peptic ulcer, gastroesophageal reflux disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 294.158
Show 2 more facts
- chemical formula
- C₁₅H₂₂N₂O₄
- canonical SMILES
- COC1=CC(=CC(=C1OC)OC)C(=O)NC2CCCNC2
via Wikidata · CC0
~9 min read
Encyclopedic overview
11 sectionsContents
- Mechanism of action
- Gastric mucosal protection
- Stimulation of cytoprotective prostaglandins
- Suppression of gastric inflammation
- Enhancement of mucosal metabolism
- Stimulation of mucosal microcirculation
- Anti-''Helicobacter pylori'' action
- Pharmacokinetics
- Clinical experience
- Safety and tolerability
- References
Troxipide is a drug used in the treatment of gastroesophageal reflux disease. Troxipide is a systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum. Troxipide is currently marketed in Japan (Aplace), China (Shuqi), South Korea (Defensa), and India (Troxip). It is used for the management of gastric ulcers, and amelioration of gastric mucosal lesions in acute gastritis and acute exacerbation of chronic gastritis.
== Mechanism of action ==
Excerpted from Wikipedia’s “troxipide” article, available under the CC BY-SA 4.0 licence.