S1PR1
Sign in to saveAlso known as CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and va
Gene data
S1PR1- Name
- sphingosine-1-phosphate receptor 1
- Type
- protein-coding
- Position
- 101,235,366–101,243,749 (+)
- Aliases
- CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
- Ensembl
- ENSG00000170989
- RefSeq RNA
- NM_001320730.2, NM_001400.5, NR_174345.1, NR_174346.1, NR_174347.1
- RefSeq protein
- NP_001307659.1, NP_001391.2
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sphingosine-1-phosphate receptor 1
- Symbol
- S1PR1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:101,235,366-101,243,749
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~9 min read
Encyclopedic overview
15 sectionsContents
- Structure
- Function
- Immune system
- Immune cell trafficking
- Immune cell regulation
- Vasculogenesis
- Clinical significance
- Cancer
- Multiple sclerosis
- Evolution
- [[Sequence homology|Paralogues]] for S1PR1 [[Gene]]
- Interactions
- See also
- References
- External links
Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.
== Structure ==
Excerpted from Wikipedia’s “S1PR1” article, available under the CC BY-SA 4.0 licence.
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