Structure via PubChem · Public domain (PubChem)
ساردوتانت
Sign in to saveAlso known as SR 48,968, SR 48968, SR-48,968, SR48968, Saredutant
Saredutant (SR-48,968) is a drug that acts as a NK2 receptor antagonist. It was under development by Sanofi-Aventis as a novel antidepressant and anxiolytic and made it to phase III clinical trials. However, in May 2009, Sanofi-Aventis published its quarterly results and announced the cessation of 14 research/development projects, among which was saredutant for the treatment of major depressive disorder.
Chemical data
- Formula
- C31H35Cl2N3O2
- Molecular weight
- 552.5 g/mol
- IUPAC name
- N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide
- SMILES
- CC(=O)NC1(CCN(CC1)CC[C@H](CN(C)C(=O)C2=CC=CC=C2)C3=CC(=C(C=C3)Cl)Cl)C4=CC=CC=C4
- InChIKey
- PGKXDIMONUAMFR-AREMUKBSSA-N
- XLogP
- 5.9
- Polar surface area
- 52.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- anxiety, major depressive disorder, depressive disorder
via ChEMBL · EBI
Wikidata facts
- Mass
- 551.210633
Show 3 more facts
- chemical formula
- C₃₁H₃₅Cl₂N₃O₂
- isomeric SMILES
- CC(=O)NC1(CCN(CC1)CC[C@H](CN(C)C(=O)C2=CC=CC=C2)C3=CC(=C(C=C3)Cl)Cl)C4=CC=CC=C4
- canonical SMILES
- CC(=O)NC1(CCN(CC1)CCC(CN(C)C(=O)C2=CC=CC=C2)C3=CC(=C(C=C3)Cl)Cl)C4=CC=CC=C4
Sources (2)
via Wikidata · CC0