Structure via PubChem · Public domain (PubChem)
Talnetant
Sign in to saveTalnetant (SB-223,412) is a neurokinin 3 receptor antagonist developed by GlaxoSmithKline, which is being researched for several functions (primarily treatment of irritable bowel syndrome, despite a 2007 study finding no statistically significant improvement in rectal hypersensitivity over placebo). Its use as a potential antipsychotic drug for the treatment of schizophrenia has also been discontinued.
Chemical data
- Formula
- C25H22N2O2
- Molecular weight
- 382.5 g/mol
- IUPAC name
- 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
- SMILES
- CCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)O
- InChIKey
- BIAVGWDGIJKWRM-UHFFFAOYSA-N
- XLogP
- 5.7
- Polar surface area
- 62.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 382.168128
Show 2 more facts
- chemical formula
- C₂₅H₂₂N₂O₂
- canonical SMILES
- CCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)O
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Talnetant (SB-223,412) is a neurokinin 3 receptor antagonist developed by GlaxoSmithKline, which is being researched for several functions (primarily treatment of irritable bowel syndrome, despite a 2007 study finding no statistically significant improvement in rectal hypersensitivity over placebo). Its use as a potential antipsychotic drug for the treatment of schizophrenia has also been discontinued.
== See also == Tachykinin receptor 3 § Agonists
Excerpted from Wikipedia’s “Talnetant” article, available under the CC BY-SA 4.0 licence.