vestipitant
Sign in to saveAlso known as GW597588B
Vestipitant (INN) is a drug developed by GlaxoSmithKline which acts as a selective antagonist for the NK1 receptor. It is under development as a potential antiemetic and anxiolytic drug, and as a treatment for tinnitus and insomnia.
Research
17 papers- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.The Cochrane database of systematic reviews · 2020
- Efficacy of vestipitant, a neurokinin-1 receptor antagonist, in primary insomnia.Sleep · 2013
- Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.British journal of anaesthesia · 2015
- Intravenous Pharmacokinetics, Local Tolerability, and Hemolysis of an SBE7-β-Cyclodextrin Formulation of the Neurokinin-1 Receptor Antagonist Vestipitant.Clinical pharmacology in drug development · 2015
- A randomized, controlled study comparing the effects of vestipitant or vestipitant and paroxetine combination in subjects with tinnitus.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2011
via PubMed
Wikidata facts
- Mass
- 491.18076
Show 4 more facts
- chemical formula
- C₂₃H₂₄F₇N₃O
- isomeric SMILES
- CC1=C(C=CC(=C1)F)[C@H]2CNCCN2C(=O)N(C)[C@H](C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
- canonical SMILES
- CC1=C(C=CC(=C1)F)C2CNCCN2C(=O)N(C)C(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
- Commons category
- Vestipitant
via Wikidata · CC0
~2 min read
Article
2 sectionsContents
- See also
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 399133414 | IUPAC_name = (2S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylpiperazine-1-carboxamide | image = Vestipitant structure.svg | image_class = skin-invert-image | width = 225
| tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US =
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antagonist
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nervous system
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cannabis
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insomnia
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tinnitus
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Categories
Chemical articles with multiple CAS registry numbersChemical pages without DrugBank identifierChemicals using indexlabelsDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs not assigned an ATC codeDrugs with no legal statusFluoroarenesInvestigational tinnitus drugsMultiple chemicals in Infobox drugNK1 receptor antagonistsPiperazinesTrifluoromethyl compoundsUreas