SEMA4A

Name

semaphorin 4A

Type

protein-coding

Position

156,147,366–156,178,869 (+)

Aliases

CORD10, RP35, SEMAB, SEMB

Ensembl

ENSG00000196189

RefSeq RNA

NM_001193300.2, NM_001193301.2, NM_001193302.2, NM_001370567.1, NM_001370568.1

RefSeq protein

NP_001180229.1, NP_001180230.1, NP_001180231.1, NP_001357496.1, NP_001357497.1

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].

via MyGene.info

Gene · Ensembl

semaphorin 4A

Symbol

SEMA4A

Biotype

Protein coding

Organism

Homo sapiens

Location

1:156,147,366-156,178,869

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

via Wikidata · CC0