PKP4
Sign in to saveAlso known as p0071, plakophilin 4
Plakophilin-4 is a protein that in humans is encoded by the PKP4 gene.
In the Vinony graph
Vinony's link graph records 5 inbound references to PKP4, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It sits within the topics Armadillo-repeat-containing proteins and Genes on human chromosome 2.
Vinony links it to 5 Wikipedia language editions.
Gene data
PKP4- Name
- plakophilin 4
- Type
- protein-coding
- Position
- 158,456,895–158,682,955 (+)
- Aliases
- p0071
- Ensembl
- ENSG00000144283
- RefSeq RNA
- NM_001005476.4, NM_001304969.3, NM_001304970.3, NM_001304971.2, NM_001377218.1
- RefSeq protein
- NP_001005476.1, NP_001291898.1, NP_001291899.1, NP_001291900.1, NP_001364147.1
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
plakophilin 4
- Symbol
- PKP4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:158,456,895-158,682,955
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2689
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8502
- genomic end
- 159539391
- genomic start
- 158456952
- chromosome
- human chromosome 2
- cytogenetic location
- 2q24.1
- expressed in
- middle frontal gyrus
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Plakophilin-4 is a protein that in humans is encoded by the PKP4 gene.
== Function ==
Excerpted from Wikipedia’s “PKP4” article, available under the CC BY-SA 4.0 licence.