semicarbazones
Sign in to saveAlso known as semicarbazone
thumb|right|General chemical structure of a semicarbazone thumb|right|Nitrofurazone is a semicarbazone used as an antiseptic In organic chemistry, a semicarbazone is a derivative of imines formed by a condensation reaction between a ketone or aldehyde and semicarbazide. They are classified as imine derivatives because they are formed from the reaction of an aldehyde or ketone with the terminal -NH2 group of semicarbazide, which behaves very similarly to primary amines.
Research
5,737 papers- Thio- and Semicarbazones: Hope in the Search for Treatment of Leishmaniasis and Chagas Disease.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2017
- Carbazole-based semicarbazones and hydrazones as multifunctional anti-Alzheimer agents.Journal of biomolecular structure & dynamics · 2022
- The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.Mini reviews in medicinal chemistry · 2004
- Estradiol-Based Salicylaldehyde (Thio)Semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities.Molecules (Basel, Switzerland) · 2022
- Acridine-based (thio)semicarbazones and hydrazones: Synthesis, in vitro urease inhibition, molecular docking and in-silico ADME evaluation.Bioorganic chemistry · 2019
via PubMed
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Encyclopedic overview
5 sectionsContents
- Formation
- Properties and uses
- See also
- References
- External links
thumb|right|General chemical structure of a semicarbazone thumb|right|Nitrofurazone is a semicarbazone used as an antiseptic In organic chemistry, a semicarbazone is a derivative of imines formed by a condensation reaction between a ketone or aldehyde and semicarbazide. They are classified as imine derivatives because they are formed from the reaction of an aldehyde or ketone with the terminal -NH2 group of semicarbazide, which behaves very similarly to primary amines.
==Formation== For ketones H2NNHC(=O)NH2 + RC(=O)R → R2C=NNHC(=O)NH2 For aldehydes H2NNHC(=O)NH2 + RCHO → RCH=NNHC(=O)NH2
Excerpted from Wikipedia’s “semicarbazones” article, available under the CC BY-SA 4.0 licence.