Structure via PubChem · Public domain (PubChem)
endralazine
Sign in to saveEndralazine is an antihypertensive of the hydrazinophthalazine chemical class. It is not approved for use in the United States.
Chemical data
- Formula
- C14H15N5O
- Molecular weight
- 269.3 g/mol
- IUPAC name
- (3-hydrazinyl-7,8-dihydro-5H-pyrido[4,3-c]pyridazin-6-yl)-phenylmethanone
- SMILES
- C1CN(CC2=CC(=NN=C21)NN)C(=O)C3=CC=CC=C3
- InChIKey
- ALAXZYHFVBSJKZ-UHFFFAOYSA-N
- XLogP
- 0.4
- Polar surface area
- 84.1 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- hypertension
via ChEMBL · EBI
Research
58 papers- Endralazine and sexual arousal.Lancet (London, England) · 1983
- Comparative study of endralazine and hydralazine for the treatment of hypertension uncontrolled by a beta-blocker and diuretic.Current medical research and opinion · 1986
- Endralazine, a new peripheral vasodilator. Evaluation of safety and efficacy over a 3 year period.European journal of clinical pharmacology · 1983
- Acute hemodynamic effects of endralazine: a new vasodilator for chronic refractory congestive heart failure.The American journal of cardiology · 1983
- In vivo and in vitro genotoxicity of three antihypertensive hydrazine derivatives (hydralazine, dihydralazine, and endralazine).Environmental mutagenesis · 1982
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 269.128
Show 6 more facts
- chemical formula
- C₁₄H₁₅N₅O
- defined daily dose
- 10
- canonical SMILES
- C1CN(CC2=CC(=NN=C21)NN)C(=O)C3=CC=CC=C3
- isomeric SMILES
- C1=CC=C(C=C1)C(=O)N2CCC=3C(=C/C(=N/N)/NN3)C2
- subject has role
- vasodilator agent
- Commons category
- Endralazine
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Endralazine is an antihypertensive of the hydrazinophthalazine chemical class. It is not approved for use in the United States.
== References ==
Excerpted from Wikipedia’s “endralazine” article, available under the CC BY-SA 4.0 licence.