سرپین

Also known as Serpins, Serpin Protease Inhibitors, Serpin Peptidase Inhibitors

Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases (serine protease inhibitors). They are notable for their unusual mechanism of action, in which they irreversibly inhibit their target protease by undergoing a large conformational change to disrupt the target's active site. This contrasts with the more common competitive mechanism for protease inhibitors t

Key facts

Protein family.PDB: A:1-378 B:349-379 A:1-415 A:1-415 A:1-385 A:1-385 B:1-385 B:77-433 L:76-461 I:76-461 L:76-461 I:76-461 L:76-461 L:76-461 L:76-461 L:76-461 L:76-461 L:76-461 A:78-461 I:76-461 I:76-461p I:76-461 L:76-461 I:76-461 A:76-461 I:76-461 A:1-375 B:1-375 B:1-375 A:1-375 A:1-300 A:1-55 A:1-305 I:18-392 :18-369 :45-415 B:383-415 A:43-382 A:49-376 A:43-415 A:43-415 B:378-415 A:44-382 A:43-415 A:43-415 44-415 A:43-382 B:383-415 47-415 A:43-415 A:50-383 A:43-420 B:390-420 A:47-383 A:48-383 B:42-417 F:376-406 B:374-406 B:374-406 A:119-496 A:119-496 A:25-402 A:25-402 D:25-402 D:25-402 A:25-402 A:25-402 B:26-402 A:25-402 A:25-402 A:138-498 D:101-361 A:49-415
Protein family.Symbol: Serpin, SERPIN (root symbol of family)
Protein family.Name: Serpin (serine protease inhibitor)
Protein family.image: serpin_(stressed).png
Protein family.caption: A serpin (white) with its 'reactive centre loop' (blue) bound to a protease (grey). Once the protease attempts catalysis it will be irreversibly inhibited. ()
Protein family.Pfam: PF00079
Protein family.InterPro: IPR000215
Protein family.Prosite: PDOC00256
Protein family.SCOP: 1hle
Protein family.CDD: cd00172