blood coagulation
Sign in to saveCoagulation, also known as clotting, is the process by which blood changes from a liquid to a gel forming a blood clot. The process involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. Coagulation results in hemostasis, the cessation of blood loss from a damaged vessel, allowing repair.
AI overview
Blood coagulation is the process by which blood transforms from a liquid into a gel-like clot through the activation and clumping of platelets and the buildup of a protein called fibrin. This clotting process is essential because it stops bleeding from injured blood vessels, giving the body time to repair the damage.
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Key facts
- Body process.name
- Coagulation
- Body process.image
- File:Coagulation in vivo.png
- Body process.caption
- Blood coagulation pathways in vivo showing the central role played by thrombin
- Body process.health
- Beneficial
via Wikipedia infobox
Research
145,270 papers- Coagulation for blood bankers.Clinics in laboratory medicine · 1996
- Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases.Journal of internal medicine · 2005
- Blood coagulation.Physiotherapy · 1975
- [Blood coagulation].Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete · 1954
Article
36 sectionsContents
- List of coagulation factors
- Physiology
- Vasoconstriction
- Platelet activation and platelet plug formation
- Coagulation cascade
- Tissue factor pathway (extrinsic)
- Contact activation pathway (intrinsic)
- Final common pathway
- Cell-based scheme of coagulation
- Fibrinolysis
- Role in immune system
- Cofactors
- Calcium and phospholipids
- Vitamin K
- Regulators
- Protein C and Protein S
- Antithrombin
- Tissue factor pathway inhibitor (TFPI)
- Plasmin
- Prostacyclin
- Medical assessment
- Role in disease
- Platelet disorders
- Coagulation factor disorders
- Pharmacology
- Procoagulants
- Anticoagulants
- History
- Initial discoveries
- Coagulation factors
- Nomenclature
- Other species
- See also
- References
- Further reading
- External links
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel forming a blood clot. The process involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. Coagulation results in hemostasis, the cessation of blood loss from a damaged vessel, allowing repair.
Coagulation begins almost instantly after an injury to the endothelium that lines a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial platelet tissue factor to coagulation factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: additional coagulation factors beyond factor VII (listed below) respond in a cascade to form fibrin strands, which strengthen the platelet plug.