SERPINB5
Sign in to saveAlso known as PI5, maspin, serpin family B member 5
Maspin (mammary serine protease inhibitor) is a protein that in humans is encoded by the SERPINB5 gene. This protein belongs to the serpin (serine protease inhibitor) superfamily. SERPINB5 was originally reported to function as a tumor suppressor gene in epithelial cells, suppressing the ability of cancer cells to invade and metastasize to other tissues. Furthermore, and consistent with an important biological function, Maspin knockout mice were reported to be non-viable, dying in early embryogenesis. However, a subsequent study using viral transduction as a method of gene transfer (rather tha
Gene data
SERPINB5- Name
- serpin family B member 5
- Type
- protein-coding
- Aliases
- PI5, maspin
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Located in cytoplasm. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Wikidata facts
- Image
- Protein SERPINB5 PDB 1wz9.png
Show 5 more facts
- HomoloGene ID
- 20580
- exact match
- identifiers.org/ncbigene/5268
- genomic end
- 61172318
- genomic start
- 63476958
- cytogenetic location
- 18q21.33
via Wikidata · CC0
~4 min read
Article
7 sectionsContents
- Tissue distribution
- Serpin superfamily
- Function
- Clinical significance
- References
- Further reading
- External links
Maspin (mammary serine protease inhibitor) is a protein that in humans is encoded by the SERPINB5 gene. This protein belongs to the serpin (serine protease inhibitor) superfamily. SERPINB5 was originally reported to function as a tumor suppressor gene in epithelial cells, suppressing the ability of cancer cells to invade and metastasize to other tissues. Furthermore, and consistent with an important biological function, Maspin knockout mice were reported to be non-viable, dying in early embryogenesis. However, a subsequent study using viral transduction as a method of gene transfer (rather than single cell cloning) was not able to reproduce the original findings and found no role for maspin in tumour biology. Furthermore, the latter study demonstrated that maspin knockout mice are viable and display no obvious phenotype. These data are consistent with the observation that maspin is not expressed in early embryogenesis. The precise molecular function of maspin is thus currently unknown.
== Tissue distribution ==