SERPINB9
Sign in to saveAlso known as CAP-3, CAP3, PI-9, PI9, serpin family B member 9
Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene. Serpin B9 is an inhibitor of Granzyme B (GzmB). GzmB is a potent cytotoxic molecule that is secreted by cytotoxic T lymphocytes and natural killer (NK) cells to induce apoptosis in target cells during an immune response. Serpin B9, expressed in the cytosol and nucleus, thus protects from apoptosis by cytotoxic T lymphocytes and NK cells.
In the Vinony graph
Within Vinony's link graph, SERPINB9 is referenced by 35 other articles, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.
Vinony files it under Genes on human chromosome 6 and Serine protease inhibitors.
Its subject is documented across 6 Wikipedia language editions.
Gene data
SERPINB9- Name
- serpin family B member 9
- Type
- protein-coding
- Position
- 2,887,169–2,903,318 (−)
- Aliases
- CAP-3, CAP3, PI-9, PI9
- Ensembl
- ENSG00000170542
- RefSeq RNA
- NM_004155.6, XM_005249184.6, XM_011514678.3, XM_047418894.1, XM_054355640.1
- RefSeq protein
- NP_004146.1, XP_005249241.1, XP_011512980.1, XP_047274850.1, XP_054211615.1
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
serpin family B member 9
- Symbol
- SERPINB9
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:2,887,169-2,903,318
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 37888
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5272
- chromosome
- human chromosome 6
- genomic start
- 2887270
- genomic end
- 2903309
- cytogenetic location
- 6p25.2
- expressed in
- granulocyte
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene. Serpin B9 is an inhibitor of Granzyme B (GzmB). GzmB is a potent cytotoxic molecule that is secreted by cytotoxic T lymphocytes and natural killer (NK) cells to induce apoptosis in target cells during an immune response. Serpin B9, expressed in the cytosol and nucleus, thus protects from apoptosis by cytotoxic T lymphocytes and NK cells.
Serpin B9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM]
Excerpted from Wikipedia’s “SERPINB9” article, available under the CC BY-SA 4.0 licence.