SH3GLB1
Sign in to saveAlso known as Bif-1, PPP1R70, dJ612B15.2, CGI-61, SH3 domain containing GRB2 like endophilin B1, SH3 domain containing GRB2 like, endophilin B1
Endophilin-B1 is a protein that in humans is encoded by the SH3GLB1 gene. Endophilin-B1 belongs to the Bin/Amphiphysin/Rvs167 (BAR) family of proteins and plays a critical role in mitochondrial fission and fusion, as well as in autophagy and apoptosis. Loss of functional endophilin-B1 is seen in many different forms of cancer. The link between carcinogenesis and dysregulation of cell death pathways suggests that endophilin-B1 serves a critical tumor suppressor role in the cell, although the underlying mechanisms are not known.
Gene data
SH3GLB1- Name
- SH3 domain containing GRB2 like, endophilin B1
- Type
- protein-coding
- Position
- 86,704,510–86,748,184 (+)
- Aliases
- Bif-1, CGI-61, PPP1R70, dJ612B15.2
- Ensembl
- ENSG00000097033
- RefSeq RNA
- NM_001206651.2, NM_001206652.2, NM_001206653.2, NM_001410824.1, NM_016009.5
- RefSeq protein
- NP_001193580.1, NP_001193581.1, NP_001193582.1, NP_001397753.1, NP_057093.1
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SH3 domain containing GRB2 like, endophilin B1
- Symbol
- SH3GLB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:86,704,510-86,748,184
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- Structure
- Interactions
- References
- Further reading
Endophilin-B1 is a protein that in humans is encoded by the SH3GLB1 gene. Endophilin-B1 belongs to the Bin/Amphiphysin/Rvs167 (BAR) family of proteins and plays a critical role in mitochondrial fission and fusion, as well as in autophagy and apoptosis. Loss of functional endophilin-B1 is seen in many different forms of cancer. The link between carcinogenesis and dysregulation of cell death pathways suggests that endophilin-B1 serves a critical tumor suppressor role in the cell, although the underlying mechanisms are not known.
== Structure == thumb|left|A pseudo-atomic model of helical scaffolds formed by a truncated form of endophilin-B1. Based on a [[UCSF Chimera|ChimeraX rendering of 6UP6.]] In the presence of model biological membranes, endophilin-B1 dimers assemble into helical scaffolds around the membrane and drive its tubulation.
Excerpted from Wikipedia’s “SH3GLB1” article, available under the CC BY-SA 4.0 licence.