Simeprevir, sold under the brand name Olysio among others, is a medication used in combination with other medications for the treatment of hepatitis C. It is specifically used for hepatitis C genotype 1 and 4. Medications it is used with include sofosbuvir or ribavirin and peginterferon-alfa. Cure rates are in 80s to 90s percent. It may be used in those who also have HIV/AIDS. It is taken by mouth once daily for typically 12 weeks.
{{Drugbox | drug_name = | IUPAC_name = (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2-{[2-(4-isopropyl-1,3-thiazol-2-yl)-7-methoxy-8-methyl-4-quinolinyl]oxy}-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide | image = Simeprevir.svg | image_class = skin-invert-image | width = 200 | alt = | caption =
| pronounce = | tradename = Olysio, Sovriad, Galexos, others | Drugs.com = | MedlinePlus = a614013 | licence_EU = yes | DailyMedID = Simeprevir | pregnancy_AU = | pregnancy_category = | routes_of_administration = By mouth | ATCvet = | ATC_prefix = J05 | ATC_suffix = AP05
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).