SORT1
Sign in to saveAlso known as Gp95, LDLCQ6, NT3, NTR3, Sortilin 1
protein-coding gene in the species Homo sapiens
Gene data
SORT1- Name
- sortilin 1
- Type
- protein-coding
- Position
- 109,309,568–109,397,967 (−)
- Aliases
- Gp95, LDLCQ6, NT3, NTR3
- Ensembl
- ENSG00000134243
- RefSeq RNA
- NM_001205228.2, NM_002959.7, XM_005271100.3, XM_005271101.4, XM_054338107.1
- RefSeq protein
- NP_001192157.1, NP_002950.3, XP_005271157.1, XP_005271158.1, XP_054194082.1
This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
Gene Ontology
Biological process
Molecular function
Pathways
Lysosome - Homo sapiens (human)Neurotrophin signaling pathway - Homo sapiens (human)Cholesterol metabolism - Homo sapiens (human)Membrane Traffickingtrans-Golgi Network Vesicle BuddingGolgi Associated Vesicle BiogenesisVesicle-mediated transportBrain-derived neurotrophic factor (BDNF) signaling pathwayNeural Crest Cell Migration in Cancer
via MyGene.info
Gene · Ensembl
sortilin 1
- Symbol
- SORT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:109,309,568-109,397,967
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI