SPI1

Also known as OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.

Gene data

SPI1

Name: Spi-1 proto-oncogene
Type: protein-coding
Position: 47,354,860–47,409,369 (−)
Aliases: AGM10, OF, PU.1, SFPI1, SPI-1, SPI-A
Ensembl: ENSG00000066336
RefSeq RNA: NM_001080547.2, NM_003120.3, XM_054369738.1, XM_054369739.1
RefSeq protein: NP_001074016.1, NP_003111.2, XP_054225713.1, XP_054225714.1

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II germinal center B cell differentiation follicular B cell differentiation immature B cell differentiation defense response to tumor cell

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific

Cellular component

chromatin chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Osteoclast differentiation - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Acute myeloid leukemia - Homo sapiens (human)Developmental Biology Developmental Biology Generic Transcription Pathway RNA Polymerase II Transcription Gene expression (Transcription)

via MyGene.info

Gene · Ensembl

Spi-1 proto-oncogene

Symbol: SPI1
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:47,354,860-47,409,369
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein SPI1 PDB 1pue.png

Show 5 more facts

exact match: identifiers.org/ncbigene/6688
HomoloGene ID: 2346
genomic end: 47378547
genomic start: 47376411
cytogenetic location: 11p11.2

Sources (3)

via Wikidata · CC0

~2 min read

Article

6 sections

Contents

Function
Structure
Interactions
References
Further reading
External links

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.

== Function == This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhancers of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.