GFI1

Name

growth factor independent 1 transcriptional repressor

Type

protein-coding

Position

92,472,360–92,486,925 (−)

Aliases

GFI-1, GFI1A, SCN2, ZNF163

Ensembl

ENSG00000162676

RefSeq RNA

NM_001127215.3, NM_001127216.3, NM_005263.5, XM_005270749.4, XM_011541245.3

RefSeq protein

NP_001120687.1, NP_001120688.1, NP_005254.2, XP_005270806.1, XP_011539547.1

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

growth factor independent 1 transcriptional repressor

Symbol

GFI1

Biotype

Protein coding

Organism

Homo sapiens

Location

1:92,472,360-92,486,925

Strand

Reverse (−)

Assembly

GRCh38