STAT1

Name

signal transducer and activator of transcription 1

Type

protein-coding

Position

190,908,460–191,020,960 (−)

Aliases

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Ensembl

ENSG00000115415

RefSeq RNA

NM_001384880.1, NM_001384881.1, NM_001384882.1, NM_001384883.1, NM_001384884.1

RefSeq protein

NP_001371809.1, NP_001371810.1, NP_001371811.1, NP_001371812.1, NP_001371813.1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020].

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 1

Symbol

STAT1

Biotype

Protein coding

Organism

Homo sapiens

Location

2:190,908,460-191,020,960

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Stat1 stucture.png

via Wikidata · CC0