STAT5B

Also known as STAT5, signal transducer and activator of transcription 5B, GHISID2

gen de la especie Homo sapiens

Gene data

STAT5B

Name: signal transducer and activator of transcription 5B
Type: protein-coding
Position: 42,199,176–42,288,633 (−)
Aliases: GHISID2, STAT5
Ensembl: ENSG00000173757
RefSeq RNA: NM_012448.4, XM_005257626.5, XM_017024977.2, XM_024450897.2, XM_024450898.2
RefSeq protein: NP_036580.2, XP_005257683.1, XP_016880466.1, XP_024306665.1, XP_024306666.1

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II defense response signal transduction cell surface receptor signaling pathway via JAK-STAT cell surface receptor signaling pathway via JAK-STAT cell surface receptor signaling pathway via JAK-STAT

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding chromatin binding

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm

Pathways

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 5B

Symbol: STAT5B
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:42,199,176-42,288,633
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein STAT5B PDB 1y1u.png

Show 8 more facts

HomoloGene ID: 55718
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6777
genomic end: 40428725
genomic start: 42199177
chromosome: human chromosome 17
cytogenetic location: 17q21.2
expressed in: middle frontal gyrus

Sources (3)

via Wikidata · CC0

Article · Español

El transductor de señales y activador transcripcional 5B (STAT5B) es una proteína codificada en humanos por el gen stat5B. Esta proteína pertenece a la familia de los factores de transcripción . En respuesta a las citoquinas y a los factores de crecimiento, los miembros de la familia STAT son fosforilados por receptores asociados a quinasas, formando homo- o heterodímeros que se translocan al núcleo donde actúan como activadores transcripcionales. La proteína STAT5B es un intermediario de la transducción de señales iniciada por diferentes ligandos, tales como IL-2, IL-4, CSF-1 y diversas hormonas de crecimiento. Esta proteína también ha demostrado estar implicada en gran diversidad de procesos biológicos como la señalización TCR, la apoptosis, el desarrollo de las glándulas mamarias en mamíferos y en la expresión génica hepática implicada en el dimorfismo sexual. El gen stat5B se he encontrado fusionado al gen que codifica el receptor de ácido retinoico alfa (RARA) en algunos tipos de leucemia promielocítica aguda. La desregulación de las rutas de señalización mediadas por esta proteína podrían ser una de las causas de dicha leucemia.

Abstract from DBpedia / Wikipedia · CC BY-SA