STAT6

Name

signal transducer and activator of transcription 6

Type

protein-coding

Position

57,095,403–57,132,139 (−)

Aliases

D12S1644, HIES6, IL-4-STAT, STAT6B, STAT6C

Ensembl

ENSG00000166888

RefSeq RNA

NM_001178078.2, NM_001178079.2, NM_001178080.2, NM_001178081.2, NM_001445504.1

RefSeq protein

NP_001171549.1, NP_001171550.1, NP_001171551.1, NP_001171552.1, NP_001432433.1

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 6

Symbol

STAT6

Biotype

Protein coding

Organism

Homo sapiens

Location

12:57,095,403-57,132,139

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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