Structure via PubChem · Public domain (PubChem)
stiripentol
Sign in to saveAlso known as BCX 2600, Diacomit ®, BRN 1313047, Stiripentolum, 4,4-Dimethyl-1-((3,4-methylenedioxy)phenyl)-1-penten-3-ol, Estiripentol, 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol
Stiripentol, sold under the brand name Diacomit, is an anticonvulsant medication used for the treatment of Dravet syndrome - a serious genetic brain disorder.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 470470962
- Drug.image
- Stiripentol structure.svg
- Drug.image_class
- skin-invert-image
- Drug.pronounce
- stir"i pen' tol
- Drug.tradename
- Diacomit
- Drug.MedlinePlus
- a618069
- Drug.DailyMedID
- Stiripentol
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N03
- Drug.ATC_suffix
- AX17
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C14H18O3
- Molecular weight
- 234.29 g/mol
- IUPAC name
- (E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
- SMILES
- CC(C)(C)C(/C=C/C1=CC2=C(C=C1)OCO2)O
- InChIKey
- IBLNKMRFIPWSOY-FNORWQNLSA-N
- XLogP
- 3.6
- Polar surface area
- 38.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2007
- Admin. routes
- oral
- Indications
- epilepsy, Seizure, primary hyperoxaluria, chronic kidney disease
via ChEMBL · EBI
Research
457 papers- Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first-line add-on therapies for seizures in Dravet syndrome: A network meta-analysis.Epilepsia open · 2024
- Stiripentol.2012
- Stiripentol add-on therapy for drug-resistant focal epilepsy.The Cochrane database of systematic reviews · 2022
- Stiripentol (Diacomit) for Dravet syndrome.The Medical letter on drugs and therapeutics · 2021
- Stiripentol: A Review in Dravet Syndrome.Drugs · 2019
via PubMed
Wikidata facts
- Mass
- 234.125594
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₄H₁₈O₃
- canonical SMILES
- CC(C)(C)C(C=CC1=CC2=C(C=C1)OCO2)O
- isomeric SMILES
- CC(C)(C)C(/C=C/C1=CC2=C(C=C1)OCO2)O
- Commons category
- Stiripentol
- defined daily dose
- 1
- subject has role
- anticonvulsant agent
via Wikidata · CC0
~5 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Interactions
- Pharmacology
- Chemistry
- History
- Society and culture
- Economics
- References
Stiripentol, sold under the brand name Diacomit, is an anticonvulsant medication used for the treatment of Dravet syndrome - a serious genetic brain disorder.
The most common side effects include loss of appetite, weight loss, insomnia (difficulty sleeping), drowsiness, ataxia (inability to co‑ordinate muscle movements), hypotonia (low muscle strength) and dystonia (muscle disorders).
Excerpted from Wikipedia’s “stiripentol” article, available under the CC BY-SA 4.0 licence.