STK11

Also known as LKB1, PJS, hLKB1, serine/threonine kinase 11

Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.

Gene data

STK11

Name: serine/threonine kinase 11
Type: protein-coding
Position: 1,177,558–1,228,431 (+)
Aliases: LKB1, PJS, hLKB1
Ensembl: ENSG00000118046
RefSeq RNA: NM_000455.5, NM_001407255.1, NR_176325.1
RefSeq protein: NP_000446.1, NP_001394184.1

The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022].

Pathways

FoxO signaling pathway - Homo sapiens (human)Autophagy - animal - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Longevity regulating pathway - Homo sapiens (human)Tight junction - Homo sapiens (human)Adipocytokine signaling pathway - Homo sapiens (human)Metabolism Signal Transduction

via MyGene.info

Gene · Ensembl

serine/threonine kinase 11

Symbol: STK11
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:1,177,558-1,228,431
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: LKB1 complex structure 2WTK.png

Show 5 more facts

HomoloGene ID: 393
genomic start: 1189406
exact match: identifiers.org/ncbigene/6794
genomic end: 1228431
cytogenetic location: 19p13.3

Sources (6)

via Wikidata · CC0

~6 min read

Article

11 sections

Contents

Expression
Function
Clinical significance
Activation
Structure
Splice variants
Interactions
See also
References
Further reading
External links

Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.

==Expression== Testosterone and DHT treatment of murine 3T3-L1 or human SGBS adipocytes for 24 h significantly decreased the mRNA expression of LKB1 via the androgen receptor and consequently reduced the activation of AMPK by phosphorylation. In contrast, 17β-estradiol treatment increased LKB1 mRNA, an effect mediated by oestrogen receptor alpha.