STXBP5
Sign in to saveAlso known as LGL3, Tomosyn, LLGL3, Nbla04300, syntaxin binding protein 5
Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene. It is also known as tomosyn, after , "friend" in Japanese, for its role as a binding protein.
Gene data
STXBP5- Name
- syntaxin binding protein 5
- Type
- protein-coding
- Position
- 147,203,502–147,391,010 (+)
- Aliases
- LGL3, LLGL3, Nbla04300
- Ensembl
- ENSG00000164506
- RefSeq RNA
- NM_001127715.4, NM_001394409.1, NM_139244.6, XM_017010268.3, XM_047418197.1
- RefSeq protein
- NP_001121187.1, NP_001381338.1, NP_640337.3, XP_016865757.1, XP_047274153.1
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
via MyGene.info
Gene · Ensembl
syntaxin binding protein 5
- Symbol
- STXBP5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:147,203,502-147,391,010
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Structure
- Interactions
- References
- Further reading
Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene. It is also known as tomosyn, after , "friend" in Japanese, for its role as a binding protein.
== Function ==
Excerpted from Wikipedia’s “STXBP5” article, available under the CC BY-SA 4.0 licence.