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GeneQ18037102· pop 6· linked from 331 articles

SYNM

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Also known as DMN, SYN, synemin

Synemin, also known as desmuslin, is a protein that in humans is encoded by the SYNM gene. Synemin is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle.

Gene data

SYNM
Name
synemin
Type
protein-coding
Position
99,098,217–99,135,848 (+)
Aliases
DMN, SYN
Ensembl
ENSG00000182253
RefSeq RNA
NM_015286.6, NM_145728.3, XM_017022035.2, XM_054377622.1
RefSeq protein
NP_056101.5, NP_663780.2, XP_016877524.1, XP_054233597.1

The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

via MyGene.info

Gene · Ensembl

synemin

Symbol
SYNM
Biotype
Protein coding
Organism
Homo sapiens
Location
15:99,098,217-99,135,848
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

7 sections
Contents
  • Function
  • Properties
  • Splice variants
  • Cancer
  • History
  • References
  • External links

Synemin, also known as desmuslin, is a protein that in humans is encoded by the SYNM gene. Synemin is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle.

== Function ==

Excerpted from Wikipedia’s “SYNM” article, available under the CC BY-SA 4.0 licence.

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