Structure via PubChem · Public domain (PubChem)
prosultiamine
Sign in to saveProsultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.
Chemical data
- Formula
- C15H24N4O2S2
- Molecular weight
- 356.5 g/mol
- IUPAC name
- N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(propyldisulfanyl)pent-2-en-2-yl]formamide
- SMILES
- CCCSS/C(=C(\C)/N(CC1=CN=C(N=C1N)C)C=O)/CCO
- InChIKey
- UDCIYVVYDCXLSX-SDNWHVSQSA-N
- XLogP
- 1.1
- Polar surface area
- 143 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 356.134
Show 4 more facts
- Commons category
- Prosultiamine
- chemical formula
- C₁₅H₂₄N₄O₂S₂
- canonical SMILES
- CCCSSC(=C(C)N(CC1=CN=C(N=C1N)C)C=O)CCO
- isomeric SMILES
- CCCSS/C(=C(\C)/N(CC1=CN=C(N=C1N)C)C=O)/CCO
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Research
- See also
- References
Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B1 deficiency. It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.
==Research== It has been studied as a potential treatment for infection with human T-lymphotropic virus (HTLV), since it has been shown to reduce viral load and symptoms.
Excerpted from Wikipedia’s “prosultiamine” article, available under the CC BY-SA 4.0 licence.