OPRM1

Name

opioid receptor mu 1

Type

protein-coding

Position

154,010,496–154,246,867 (+)

Aliases

LMOR, M-OR-1, MOP, MOR, MOR1, OPRM

Ensembl

ENSG00000112038

RefSeq RNA

NM_000914.5, NM_001008503.3, NM_001008504.4, NM_001008505.2, NM_001145279.4

RefSeq protein

NP_000905.3, NP_001008503.2, NP_001008504.2, NP_001008505.2, NP_001138751.1

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013].

via MyGene.info

Gene · Ensembl

opioid receptor mu 1

Symbol

OPRM1

Biotype

Protein coding

Organism

Homo sapiens

Location

6:154,010,496-154,246,867

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Main subject

opioid

via Wikidata · CC0